AVISE CTD


The Advanced Rheumatology Test

for The Differential Diagnosis of SLE


AVISE CTD is an advanced autoimmune rheumatic disease test specifically designed to aid physicians in the differential diagnosis of systemic lupus erythematosus (SLE). AVISE CTD is the only diagnostic test powered by patented Cell-Bound Complement Activation Products (CB-CAPs), stable biomarkers of complement activation, to help physicians better assess patients with suspected SLE.

What assays are included in AVISE CTD:

AVISE CTD contains the patented Lupus (SLE) biomarkers, CB-CAPs, which help to offer a 22% greater sensitivity compared to C3/C4, and 48% greater sensitivity compared to anti-dsDNA









Clinical Utility

There are many clinical scenarios that can benefit from the AVISE CTD test including:

  • Assessment of ANA positive referrals
  • Patients with clinical suspicion of a connective tissue disease but insufficient criteria for diagnosis
  • Assessment of patients with overlapping symptoms
  • Observation of Undifferentiated Connective Tissue Disease
  • ANA positive fibromyalgia patients with clinical suspicion of underlying autoimmune inflammatory disease

State-of-the-art Methods:

Accurate results depend on reliable test methods. That’s why AVISE CTD measures ANA by IFA using digital imaging as well as ELISA, and confirms positive ds-DNA results using immunofluorescence Crithidia assay.

All markers reported in AVISE CTD are carefully selected to provide maximum performance in the diagnosis of SLE and diseases that mimic lupus.


AVISE CTD is composed of an advanced two-tier lupus test assessment to help provide physicians the information needed to make a confident lupus diagnosis.



Understanding how the AVISE Index Value is Calculated:


Interactive Test Report

    The AVISE Interactive Test Report (IRR) and IRR video are intended to be used as educational tools for health care providers ONLY. The IRR is NOT intended to be used to diagnose or treat patients. The use of the Integrative Test Report by any third party, outside laboratory consultants or academic institutions is explicitly prohibited. The replication of the IRR without explicit permission from Exagen Diagnostics is prohibited under penalty of law.

AVISE CTD Test Report

References:

  1. Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE.
  2. Cell-bound complement activation products in SLE. Ramsey-Goldman R, et al. Lupus Science and Medicine. 2017.
  3. Cell-bound complement activation products in systemic lupus erythematosus: comparison with anti-double-stranded DNA and standard complement measurements. Putterman C. et al. Lupus Science and Medicine. 2014.
  4. Systemic lupus erythematosus and primary fibromyalgia can be distinguished by testing for cell-bound complement activation products. Wallace D. et al. Lupus Science & Medicine. 2016.
  5. The AVISE Lupus Test and Cell-bound Complement Activation Products Aid the Diagnosis of Systemic Lupus Erythematosus. Mossell J. et al. The Open Rheumatology Journal. 2016.

View Complete References

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