AVISE MTX


The Methotrexate Polyglutamates Test



AVISE® MTX provides accurate measurement of active methotrexate (MTX) metabolites, methotrexate polyglutamates (MTXPGs) to help physicians appropriately assess their patients' exposure to methotrexate.

The AVISE MTX test is available via venous draw and through AVISE® Touch low volume capillary draw device.

AVISE MTX helps assess variability in methotrexate pharmacokinetics.


Image

Clinical Utility:

The AVISE MTX test is intended for use in patients on methotrexate treatment, after steady state (approx. 90 days), to help assess the following:


Therapeutic decision making including:

  • Drug delivery route, i.e. oral vs. subcutaneous MTX therapy
  • Treatment changes


Image

AVISE MTX Test Report

References:

  1. Dervieux T, Furst D, et al. Polyglutamation of Methotrexate With Common Polymorphisms in Reduced Folate Carrier, Aminoimidazole Carboxamide Ribonucleotide Transformylase, and Thymidylate Synthase Are Associated With Methotrexate Effects in Rheumatoid Arthritis, Arthritis Rheum. 2004; 50(9):2766-2774.
  2. Dervieux T, Furst D, et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentered cross sectional observational study, Ann Rheum Dis 2005;64(8):1180-1185.
  3. Dervieux T, Greenstein N, et al. Pharmacogenomic and Metabolic Biomarkers in the Folate Pathway and Their Association With Methotrexate Effects During Dosage Escalation in Rheumatoid Arthritis, Arthritis Rheum. 2006;54(10):3095-3103.

View Complete References

To learn more about AVISE testing please click the link below.


Learn More